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Assistant Professor

PUBLICATIONS:

G. Han, K. Khosla, K. T. Smith, D. W. H. Ng, JiYong Lee, X. Ouyang, J. C. Bischof, and M. C. McAlpine*, 3D Printed Organisms Enabled by Aspiration-Assisted Adaptive Strategies, Advanced Science, 2404617 (2024)

J. Kim, H. Kim, S.H Park, S. Y. Han, H. Hong, Y. J. Kim, JiYong Lee, J. Kim, S.-W. Cho, W.H. Ryu. Individually-addressable composite microneedle electrode array by mold-and-place method for glucose detection, Sensors and Actuators B: Chemical, Vol. 401, 134884 (2024)

Y. Kang†, JiYong Lee†, S.H. Park, J. H. Kim, S. I. Kim, and W.H. Ryu*, Balloon Catheter-integrated Piezoelectric Micro-pyramid Arrays for Measuring Vascular Stiffness, ACS Applied Materials & Interfaces, Vol.15, No.14, 17653–17663 (2023) †Equally contributed

E.H. Jang, J. Ryu, J.-H. Kim, JiYong Lee, W.H. Ryu, and Y.-N. Youn*. Effect of sequential release of sirolimus and rosuvastatin using silk fibroin microneedle to prevent intimal hyperplasia, Biomedicine & Pharmacotherapy, Vol. 168, 115702 (2023)

C. Liu†, J.-T. Kim†, D. S. Yang†, D. Cho†, S. Yoo, S. R. Madhvapathy, H. Jeong, T. Yang, H. Luan, R. Avila, J. Park, Y. Wu, K. Bryant, M. Cho, JiYong Lee, J. Kwak, W. Ryu, Y. Huang*, R. G. Nuzzo*, and J. A. Rogers*, Multifunctional Materials Strategies for Enhanced Safety of Wireless, Skin-Interfaced Bioelectronic Devices, Advanced Functional Materials, 2302256 (2023) †Equally contributed.

J.-H. Kim, E. H. Jang, J.-Y. Ryu, JiYong Lee, J. H. Kim, W. Ryu, Y.-N. Youn* Sirolimus-Embedded Silk Microneedle Wrap to Prevent Neointimal Hyperplasia in Vein Graft Model, International Journal of Molecular Science, Vol 24. No.4, 3306 (2023)

Y. Kim, JiYong Lee, H. Hong, S. Park, and W.H. Ryu*, Self-powered Wearable Micropyramid Piezoelectric Film Sensor for Real Time Monitoring of Blood Pressure, Advanced Engineering Materials, Vol.25 No.2 2200873 (2022)

Y. Xue, H. Kim, J. Lee, Y. Liu, T. Hoffman, Y. Chen, X. Wu, W. Sun, S. Zhang, H. Cho, JiYong Lee, H. Kang, W. Ryu, C. Lee, S. Ahadian, M.R. Dokmeci, B. Lei, K. Lee*, A. Khademhosseini*, Co-electrospun Silk Fibroin and Gelatin Methacryloyl Sheet Seeded with Mesenchymal Stem Cells for Tendon Regeneration, Small, 2107714, accepted (2022)

E. H. Jang, J.-H. Kim, J. Ryu, JiYong Lee, H.-H Kim and Y.-N. Youn*, Time-dependent pathobiological and physiological changes of implanted vein grafts in a canine model, Journal of Cardiovascular Translational Research, 1-11 (2022)

JiYong Lee, E. H. Jang, J. H. Kim, S.H. Park, Y. Kang, S. Park, K.J. Lee, J.-H. Kim, Y.-N. Youn*, and W.H. Ryu*, Highly Flexible and Porous Silk Fibroin Microneedle Wraps for Perivascular Drug Delivery, Journal of Controlled Release, Vol.340, 125-135 (2021) Selected as the Outside Front Coverof 2021. Vol. 340

S.H. Park, Y. J. Kim, S. Park, H. Hong, JiYong Lee, S. I. Kim, K. Lee, and W.H. Ryu*, Rapid Extraction and Detection of Biomolecules via a Microneedle Array of Wet-crosslinked Methacrylated Hyaluronic Acid, Advanced Materials Technologies, 2100874 (2021)

S.H. Park, K.J. Lee, H. Kang, Y. Lee, JiYong Lee, J. H. Kim, H. B. Song*, and W.H. Ryu*, Single administration of a biodegradable, separable microneedle can substitute for repeated application of eyedrops in the treatment of infectious keratitis, Advanced Healthcare Materials, Vol.10, No.11, 2002287 (2021)

K.J. Lee, JiYong Lee, S. G. Lee, S.H. Park, D.S. Yang, J.-J. Lee, A. Khademhosseini, J. S. Kim, and W.H. Ryu*, Microneedle drug eluting balloon for enhanced drug delivery to vascular tissue, Journal of Controlled Release, Vol.321, 174-183 (2020)

K.J. Lee, S.H. Park, JiYong Lee, S. Ryu, C.Joo, and W.H. Ryu*, Three-Step Thermal Drawing for Rapid Prototyping of Highly Customizable Microneedles for Vascular Tissue Insertion, Pharmaceutics, Vol.11, No.3, 100-112 (2019)

S. K. Jeon, JiYong Lee, H. S. Hwang, W.H. Ryu* and Y. Chae*, A parasitic insensitive catheter-based capacitive force sensor for cardiovascular diagnosis, IEEE Transactions on Biomedical Circuits. and Systems, Vol.12, No.4, 7614-7625 (2018)

JiYong Lee, D.-H. Kim, K. J. Lee, I. H. Seo, S. H. Park, E. H. Jang, Y. Park, Y.-N. Youn*, and W.H. Ryu*, Transfer-molded wrappable microneedle meshes for perivascular drug delivery, Journal of Controlled Release, Vol.268, 237-246 (2017)

D.-H. Kim, E. H. Jang, K. J. Lee, JiYong Lee, S. H. Park, I. H. Seo, K. W. Lee, S. H. Lee, W.H. Ryu*, and Y.-N. Youn*, A Biodegradable Microneedle Cuff for Comparison of Drug Effects through Perivascular Delivery to Balloon-Injured Arteries, Polymers, Vol.9, No.2, 56-68 (2017)

E. Ko, J. S. Lee, H. Kim, S. Y. Yang, D. Yang, K. Yang, JiYong Lee, J. Shin, H. S. Yang, W.H. Ryu*, and S.-W. Cho*, Electrospun Silk Fibroin Nanofibrous Scaffolds with Two-Stage Hydroxyapatite Functionalization for Enhancing the Osteogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells, ACS applied materials & interfaces, Vol.10, No.9, 7614-7625 (2017)

H.B. Sim, JiYong Lee, B. Park, S. J. Kim, S. Kang, W.H. Ryu*, and S. C. Jun*, High-concentration dispersions of exfoliated MoS2 sheets stabilized by freeze-dried silk fibroin powder, Nano Research, Vol.9, No.6, 1709-1722 (2016)

S. H. Park, K. J. Lee, JiYong Lee, J. H. Yoon, D. H. Jo, J. H. Kim, K. Kang, and W.H. Ryu*, Microneedle-based minimally-invasive measurement of puncture resistance and fracture toughness of sclera, Acta Biomaterialia, Vol.44, No.15, 286-294 (2016)

D. Yang, H. Kim, JiYong Lee, H. Jeon, and W.H. Ryu*, Direct modulus measurement of single composite nanofibers of silk fibroin/hydroxyapatite nanoparticles, Composites Science and Technology, Vol.122, No.18, 113-121 (2016)

JiYong Lee, S. H. Park, I. H. Seo, K. J. Lee, and W.H. Ryu*, Rapid and repeatable fabrication of high A/R silk fibroin microneedles using thermally-drawn micromolds, European Journal of Pharmaceutics and Biopharmaceutics, Vol.94, 11-19 (2015)

H. B. Song, K. J. Lee, I. H. Seo, JiYong Lee, S.-M. Lee, J. H. Kim, J. H. Kim*, and W.H. Ryu*, Impact insertion of transfer-molded microneedle for localized and minimally invasive ocular drug delivery, Journal of Controlled Release, Vol.209, 272-279 (2015)

K. J. Lee, S. H. Park, JiYong Lee, H. C. Joo, E. H. Jang, Y.-N. Youn*, and W.H. Ryu*, Perivascular biodegradable microneedle cuff for reduction of neointima formation after vascular injury, Journal of Controlled Release, Vol.192, 174-181 (2014)


BOOK CHAPTERS:

K. J. Lee, S. H. Park, JiYong Lee, and W.H. Ryu*, Commercialized Microneedles (Ch. 9, pp 91- 108) in "Microneedling in Clinical Practice" (CRC Press, 2020.10.02) Ed. by. B. Stoeber, R. K. Sivamani, H. I. Maibach, eBook ISBN (9781315265612)

Patents:

  • W.H. Ryu, JiYong Lee, S.H. Park and J.H. Kim, “MICRONEEDLE PATCH, MICRONEEDLE SYSTEM, AND METHOD OF FABRICATING THE SAME”, US Patent, 11697009 (2023).

  • W.H. Ryu, JiYong Lee, J.M. Kim, “BIOLOGICAL DATA ACQUISITION APPARATUS AND BIOLOGICAL DATA PROCESSING APPARATUS USING THE SAME”, Korea Patent, 10-2742895 (2024).

  • W.H. Ryu, Y.-N. Youn, JiYong Lee, E. H. Jang, and J. H. Kim, “DRUG DELIVERY STENT, METHOD OF FABRICATING THEREOF AND METHOD OF DELIVERING DRUG USING THE SAME”, Korea Patent, 10-2428943 (2022).

  • W.H. Ryu, Y-N. Youn, JiYong Lee, E. H. Jang, and J. H. Kim, “DRUG DELIVERY DEVICE AND METHOD OF DRUG DELIVERING USING THE SAME”, Korea Patent, 10-2428946 (2022).

  • W.H. Ryu, JiYong Lee, S.H. Park and J.H. Kim, “MICRO-NEEDLE PATCH AND METHOD OF FABRICATING THE SAME”, Korea Patent, 10-2297112 (2021).

  • W.H. Ryu, JiYong Lee, S.H. Park and J.H. Kim, “MICRO-NEEDLE PATCH AND MICRO-NEEDLE SYSTEM”, Korea Patent, 10-2323528 (2021).

  • W.H. Ryu, JiYong Lee, and Y.-N. Youn, “MESH FOR MEDICAL HAVING MICRO NEEDLES AND MANUFACTURING METHOD THEREOF”, Korea Patent, 10-1850957 (2018).

  • S. C. Jun, H. B. Sim, W.H. Ryu, S. Kim, Y. S. H. Han, and JiYong Lee, “EXFOLIATIONG METHOD OF SEMICONDUCTING MATERIAL FOR PREPARING 2D MATERIAL USING SILK”, Korea Patent, 10-1633631 (2016).

  • W.H. Ryu, JiYong Lee, J.M. Kim, “BIOLOGICAL DATA ACQUISITION APPARATUS AND BIOLOGICAL DATA PROCESSING APPARATUS USING THE SAME”, US Patent, 17/520,130 (pending).

  • W.H. Ryu, Y.-N. Youn, JiYong Lee, E. H. Jang, and J. H. Kim, “DRUG DELIVERY STENT, METHOD OF FABRICATING THEREOF AND METHOD OF DELIVERING DRUG USING THE SAME”, International Patent, PCT/KR2021/013794 (pending).

  • W.H. Ryu, JiYong Lee, and J. Kim, “MEDICAL BALLOON CATHETER SENSOR MICRONEEDLE FORMED THEREIN”, Korea Patent, 10-2020-0148092 (pending).

  • W.H. Ryu, JiYong Lee, S.H. Park and J.H. Kim, “MICRONEEDLE PATCH AND METHOD OF FABRICATING THE SAME”, Korea Patent, 10-2019-0110987 (pending).